Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism

J Pharmacol Exp Ther. 1973 Oct;187(1):185-94.
No abstract available

MeSH terms

  • Acetaminophen / metabolism*
  • Animals
  • Chemical and Drug Induced Liver Injury / etiology*
  • Chemical and Drug Induced Liver Injury / pathology
  • Cobalt / pharmacology
  • Dose-Response Relationship, Drug
  • Drug Synergism
  • Kidney / pathology
  • Lethal Dose 50
  • Liver / pathology
  • Male
  • Methylcholanthrene / pharmacology
  • Mice
  • Mice, Inbred Strains
  • Necrosis / chemically induced
  • Phenobarbital / pharmacology
  • Piperonyl Butoxide / pharmacology
  • Rats
  • Species Specificity
  • Time Factors
  • Tritium

Substances

  • Tritium
  • Acetaminophen
  • Cobalt
  • Methylcholanthrene
  • Piperonyl Butoxide
  • Phenobarbital