On the cerebral accumulation of ketamine and the relationship between metabolism of the drug and its pharmacological effects

J Pharmacol Exp Ther. 1974 May;189(2):351-8.
No abstract available

MeSH terms

  • Animals
  • Brain / cytology
  • Brain / metabolism*
  • Cerebral Cortex / metabolism
  • Depression, Chemical
  • Dialysis
  • Dinitrophenols / pharmacology
  • Half-Life
  • In Vitro Techniques
  • Iodoacetates / pharmacology
  • Ketamine / metabolism*
  • Ketamine / pharmacology
  • Liver / metabolism
  • Male
  • Phenobarbital / pharmacology
  • Proadifen / pharmacology
  • Rats
  • Stimulation, Chemical
  • Subcellular Fractions / metabolism

Substances

  • Dinitrophenols
  • Iodoacetates
  • Ketamine
  • Proadifen
  • Phenobarbital