Detoxification reactions in isolated hepatocytes. Role of glutathione peroxidase, catalase, and formaldehyde dehydrogenase in reactions relating to N-demethylation by the cytochrome P-450 system

J Biol Chem. 1978 Sep 10;253(17):6031-7.
No abstract available

MeSH terms

  • Aldehyde Oxidoreductases / metabolism*
  • Animals
  • Catalase / metabolism*
  • Cytochrome P-450 Enzyme System / metabolism*
  • Formaldehyde
  • Formates
  • Glutathione Peroxidase / metabolism*
  • Hydrogen Peroxide
  • In Vitro Techniques
  • Kinetics
  • Liver / drug effects
  • Liver / enzymology*
  • Male
  • Oxidation-Reduction
  • Oxidoreductases, N-Demethylating / metabolism*
  • Peroxidases / metabolism*
  • Phenobarbital / pharmacology
  • Rats

Substances

  • Formates
  • Formaldehyde
  • Cytochrome P-450 Enzyme System
  • Hydrogen Peroxide
  • Peroxidases
  • Catalase
  • Glutathione Peroxidase
  • Aldehyde Oxidoreductases
  • Oxidoreductases, N-Demethylating
  • Phenobarbital