Antigens encoded by the 3'-terminal region of human T-cell leukemia virus: evidence for a functional gene

Science. 1984 Oct 5;226(4670):57-61. doi: 10.1126/science.6089350.

Abstract

Antibodies in sera from patients with adult T-cell leukemia-lymphoma or from healthy carriers of type I human T-cell leukemia virus (HTLV) recognize an antigen of approximately 42 kilodaltons (p42) in cell lines infected with HTLV-I. Radiolabel sequence analysis of cyanogen bromide fragments of p42 led to the conclusion that this antigen is encoded in part by LOR, a conserved portion of the "X" region that is flanked by the envelope gene and the 3' long terminal repeat of HTLV-I. It is possible that this novel product mediates the unique transformation properties of the HTLV family.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Antigens, Viral / genetics*
  • Base Sequence
  • Cell Line
  • Cyanogen Bromide
  • Deltaretrovirus / genetics*
  • Deltaretrovirus / immunology
  • Genes, Viral*
  • Humans
  • Peptide Fragments
  • Trans-Activators
  • Viral Proteins / genetics*

Substances

  • Antigens, Viral
  • Peptide Fragments
  • Trans-Activators
  • Viral Proteins
  • Cyanogen Bromide