Abstract
We have purified the human T-cell growth factor (interleukin-2) receptor and have cloned, sequenced and expressed cDNAs corresponding to this receptor. We identify one gene, but two interleukin-2 receptor mRNAs which differ in their polyadenylation signals. We have isolated an additional cDNA that may correspond to an alternatively spliced mRNA that lacks a 216 base segment and appears to encode an altered membrane protein which cannot bind interleukin-2.
MeSH terms
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Amino Acid Sequence
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Base Sequence
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Cloning, Molecular*
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DNA / metabolism*
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Deltaretrovirus / genetics
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Genes*
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Genes, Viral
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Humans
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Nucleic Acid Hybridization
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Protein Biosynthesis
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RNA, Messenger / genetics
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Receptors, Antigen, T-Cell / genetics*
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Receptors, Immunologic / genetics*
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Receptors, Immunologic / isolation & purification
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Receptors, Interleukin-2
Substances
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RNA, Messenger
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Receptors, Antigen, T-Cell
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Receptors, Immunologic
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Receptors, Interleukin-2
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DNA
Associated data
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GENBANK/K03122
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GENBANK/X01057
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GENBANK/X01058
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GENBANK/X01402