Abstract
Insulin-induced hypoglycemia increases the capacity for catecholamine biosynthesis in the rat adrenal medulla by two temporally distinct processes: a rapid increase in the affinity of tyrosine hydroxylase (TH) for cofactor and a more gradual increase in the maximal TH activity. Cold exposure leads to comparable long-term increases in adrenal TH activity, apparently without causing a prior activation of TH.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adrenal Medulla / drug effects*
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Adrenal Medulla / enzymology
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Animals
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Cold Temperature*
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Enzyme Activation
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Homeostasis
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Hypoglycemia / chemically induced*
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Hypoglycemia / enzymology
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Insulin / pharmacology*
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Male
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Rats
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Rats, Inbred Strains
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Stress, Physiological / enzymology*
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Tyrosine 3-Monooxygenase / metabolism*
Substances
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Insulin
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Tyrosine 3-Monooxygenase