Abstract
Monoclonal antibodies with affinity for Thy-1.2 on thymocytes also can bind to actin within marsupial, murine, and human cells. A similar cross-reactivity between Thy-1.1 and vimentin was revealed by Dulbecco and co-workers employing monoclonals. A computer-assisted analysis of the amino acid composition provided suggestive evidence for the occurrence of sequence homology between Thy-1.1 or Thy-1.2, actin, and vimentin that likely accounts for the serologic relatedness detected by hybridoma antibodies.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Actins / immunology*
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Animals
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Antibodies, Monoclonal / immunology*
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Antigens, Surface / immunology*
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Binding Sites, Antibody
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Cross Reactions
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Cytoskeleton / immunology
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Humans
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Immunologic Capping
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Intermediate Filament Proteins / immunology
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Macropodidae
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Mice
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Mice, Inbred Strains
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T-Lymphocytes / immunology
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T-Lymphocytes / ultrastructure
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Thy-1 Antigens
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Vimentin
Substances
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Actins
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Antibodies, Monoclonal
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Antigens, Surface
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Intermediate Filament Proteins
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Thy-1 Antigens
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Vimentin