Environmental and human isolates of Vibrio cholerae and Vibrio parahaemolyticus produce a Shigella dysenteriae 1 (Shiga)-like cytotoxin

Lancet. 1984 Jan 14;1(8368):77-8. doi: 10.1016/s0140-6736(84)90006-0.

Abstract

Some strains of Vibrio parahaemolyticus, Vibrio cholerae, and non-O1 V cholerae produce a bacterial-cell-associated, heat-stable material that is cytotoxic for hela cells. Cytotoxicity is completely neutralised by antibody to purified Shigella dysenteriae 1 (Shiga) toxin but not by antibody to purified cholera toxin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Toxins / biosynthesis*
  • Bacterial Toxins / immunology
  • Cholera / microbiology
  • Cholera Toxin / biosynthesis
  • Cross Reactions
  • Dysentery, Bacillary / microbiology
  • HeLa Cells
  • Humans
  • Neutralization Tests
  • Shiga Toxins
  • Shigella dysenteriae / immunology
  • Shigella dysenteriae / metabolism*
  • Vibrio cholerae / isolation & purification
  • Vibrio cholerae / metabolism*
  • Vibrio parahaemolyticus / isolation & purification
  • Vibrio parahaemolyticus / metabolism*

Substances

  • Bacterial Toxins
  • Shiga Toxins
  • Cholera Toxin