Abstract
The hybridoma antibody TL5, which precipitates the EGF receptor from the human epidermoid carcinoma cell line A431, has been shown to recognize the blood-group-A carbohydrate structure. This conclusion has been reached from studies of (a) the binding of the antibody to glycoproteins and haemagglutination of erythrocytes with known blood-group-antigen activities and (b) the inhibition of binding of the antibody to a radiolabelled blood-group-A-active glycoprotein by structurally defined oligosaccharides.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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ABO Blood-Group System / immunology*
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Animals
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Antibodies, Monoclonal / immunology*
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Antibody Specificity
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Carcinoma, Squamous Cell / immunology
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Epitopes / immunology
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ErbB Receptors
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Glycoproteins / immunology
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Hemagglutination Tests
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Humans
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Hybridomas / immunology
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Mice
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Oligosaccharides / pharmacology
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Receptors, Cell Surface / immunology*
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Structure-Activity Relationship
Substances
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ABO Blood-Group System
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Antibodies, Monoclonal
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Epitopes
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Glycoproteins
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Oligosaccharides
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Receptors, Cell Surface
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ErbB Receptors