[Stimulation of cholinergic receptors and changes in cyclic nucleotide levels in the cerebral cortex of the guinea pig]

Boll Soc Ital Biol Sper. 1982 May 15;58(9):572-7.
[Article in Italian]

Abstract

The effect of Atropine and Physostigmine on 3'5' AMP and 3'5' GMP content was investigated in slices of guinea-pig cerebral cortex maintained at rest or electrically-stimulated. Atropine and Physostigmine did not modify either the basal content or the electrically-evoked increase of 3'5' AMP and 3'5' GMP. On the contrary, Betanechol 25 micro M significantly increased 3'5' GMP and 3'5' AMP content in slices kept at rest. The effect was abolished by Atropine 1,5 x 10(-7) M and d-tubocurarine 7 x 10(-6) M, respectively.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Atropine / pharmacology
  • Bethanechol Compounds / pharmacology
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / metabolism*
  • Cyclic AMP / metabolism*
  • Cyclic GMP / metabolism*
  • Electric Stimulation
  • Guinea Pigs
  • Physostigmine / pharmacology
  • Receptors, Cholinergic / metabolism*
  • Tubocurarine / pharmacology

Substances

  • Bethanechol Compounds
  • Receptors, Cholinergic
  • Atropine
  • Physostigmine
  • Cyclic AMP
  • Cyclic GMP
  • Tubocurarine