Abstract
A cDNA clone corresponding to a mRNA present at elevated levels in transformed fibroblasts encodes a Qa/Tla class I major histocompatibility complex (MHC) antigen. High levels of this mRNA are found in all tumour cells tested; the transcript can undergo alternative splicing; and a repetitive sequence within the transcription unit has the characteristics of a transposable element. The immunological implications of MHC gene activation in tumour cells are discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens, Surface / genetics*
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Base Sequence
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Cell Line
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Cell Transformation, Viral*
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DNA Transposable Elements
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Gene Expression Regulation
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Histocompatibility Antigens Class I*
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Major Histocompatibility Complex*
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Mice
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RNA Splicing
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Repetitive Sequences, Nucleic Acid
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Teratoma / genetics
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Transcriptional Activation
Substances
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Antigens, Surface
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DNA Transposable Elements
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Histocompatibility Antigens Class I
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Q surface antigens