Activation of a Qa/Tla class I major histocompatibility antigen gene is a general feature of oncogenesis in the mouse

Nature. 1983;306(5945):756-60. doi: 10.1038/306756a0.

Abstract

A cDNA clone corresponding to a mRNA present at elevated levels in transformed fibroblasts encodes a Qa/Tla class I major histocompatibility complex (MHC) antigen. High levels of this mRNA are found in all tumour cells tested; the transcript can undergo alternative splicing; and a repetitive sequence within the transcription unit has the characteristics of a transposable element. The immunological implications of MHC gene activation in tumour cells are discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Surface / genetics*
  • Base Sequence
  • Cell Line
  • Cell Transformation, Viral*
  • DNA Transposable Elements
  • Gene Expression Regulation
  • Histocompatibility Antigens Class I*
  • Major Histocompatibility Complex*
  • Mice
  • RNA Splicing
  • Repetitive Sequences, Nucleic Acid
  • Teratoma / genetics
  • Transcriptional Activation

Substances

  • Antigens, Surface
  • DNA Transposable Elements
  • Histocompatibility Antigens Class I
  • Q surface antigens

Associated data

  • GENBANK/X00246