Transfer of sensitised Lyt 2+ cells triggers acute rejection of pancreatic islet allografts

Aust J Exp Biol Med Sci. 1983 Apr:61 (Pt 2):181-5. doi: 10.1038/icb.1983.16.

Abstract

The cellular requirements for rejection of cultured islet allografts, a tissue expressing only class I alloantigens, have been studied. The results obtained show that sensitised Thy 1+, Lyt 2+ lymphocytes and not Lyt 2- lymphocytes trigger acute graft rejection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antigens, Ly / classification
  • Antigens, Ly / immunology*
  • Diabetes Mellitus, Experimental / therapy
  • Graft Rejection*
  • Immunization, Passive
  • Islets of Langerhans Transplantation*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred CBA
  • Phenotype
  • T-Lymphocytes / classification
  • T-Lymphocytes / immunology
  • T-Lymphocytes / transplantation*

Substances

  • Antigens, Ly