Abstract
The cellular requirements for rejection of cultured islet allografts, a tissue expressing only class I alloantigens, have been studied. The results obtained show that sensitised Thy 1+, Lyt 2+ lymphocytes and not Lyt 2- lymphocytes trigger acute graft rejection.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antigens, Ly / classification
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Antigens, Ly / immunology*
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Diabetes Mellitus, Experimental / therapy
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Graft Rejection*
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Immunization, Passive
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Islets of Langerhans Transplantation*
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Male
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Mice
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Mice, Inbred BALB C
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Mice, Inbred CBA
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Phenotype
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T-Lymphocytes / classification
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T-Lymphocytes / immunology
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T-Lymphocytes / transplantation*