Hydrogen peroxide as a source of molecular oxygen for in vitro mammalian CNS preparations

Brain Res. 1983 Nov 14;278(1-2):387-93. doi: 10.1016/0006-8993(83)90280-9.

Abstract

Using an isolated neonatal rat spinal cord preparation, we have studied the ability of hydrogen peroxide to act as a source of oxygen for mammalian central nervous system (CNS) maintained in vitro. We report here that hydrogen peroxide, in low concentrations (0.001-0.004%), can effectively provide the only source, or act as a supplementary source of oxygen. This is brought about via the intracellular enzyme catalase which catalyzes the conversion of H2O2 into molecular oxygen and water.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Animals, Newborn / physiology
  • Carbon Dioxide / pharmacology
  • Histological Techniques*
  • Hydrogen Peroxide* / pharmacology
  • Hypoxia / prevention & control
  • In Vitro Techniques
  • Nitrogen / pharmacology
  • Oxygen* / pharmacology
  • Rats
  • Reflex, Monosynaptic / drug effects
  • Spinal Cord / physiology*

Substances

  • Carbon Dioxide
  • Hydrogen Peroxide
  • Nitrogen
  • Oxygen