High CSF lactate and pyruvate content in Kearns-Sayre syndrome

Neurology. 1984 Feb;34(2):253-5. doi: 10.1212/wnl.34.2.253.

Abstract

We studied lactate and pyruvate concentrations in CSF and blood of a patient with Kearns-Sayre syndrome (KSS), 3 patients with ocular myopathy and 11 normal control subjects. We found significant elevation of lactate and pyruvate in the CSF of the patient with KSS, suggesting a disorder of CNS lactate-pyruvate metabolism.

Publication types

  • Case Reports
  • Comparative Study

MeSH terms

  • Adult
  • Female
  • Humans
  • Kearns-Sayre Syndrome / cerebrospinal fluid*
  • Kearns-Sayre Syndrome / pathology
  • Lactates / cerebrospinal fluid*
  • Male
  • Middle Aged
  • Mitochondria, Muscle / ultrastructure
  • Ophthalmoplegia / cerebrospinal fluid*
  • Pyruvates / cerebrospinal fluid*

Substances

  • Lactates
  • Pyruvates