The effect of metrizamide on regional brain glucose metabolism in the rat

Acta Neurol Scand. 1984 Apr;69(4):249-53. doi: 10.1111/j.1600-0404.1984.tb07808.x.

Abstract

The X-ray contrast material metrizamide is structurally related to 2-deoxyglucose and inhibits brain glucose phosphorylation in vitro. In vivo, the present autoradiographic study with labeled 2-deoxyglucose revealed a global reduction of brain glucose phosphorylation after metrizamide administration in the cisterna magna of rats. The reduction averaged 18% of all regions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / metabolism*
  • Cisterna Magna
  • Deoxy Sugars / metabolism*
  • Deoxyglucose / metabolism*
  • Male
  • Metrizamide / administration & dosage
  • Metrizamide / pharmacology*
  • Oxidative Phosphorylation / drug effects
  • Rats
  • Rats, Inbred Strains

Substances

  • Deoxy Sugars
  • Deoxyglucose
  • Metrizamide