Aspirin-like drugs inhibit arachidonic acid metabolism via lipoxygenase and cyclo-oxygenase in rat neutrophils from carrageenan pleural exudates

Biochem Biophys Res Commun. 1980 Jan 29;92(2):688-95. doi: 10.1016/0006-291x(80)90388-5.
No abstract available

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Arachidonic Acids / metabolism*
  • Aspirin / pharmacology
  • Dose-Response Relationship, Drug
  • Indomethacin / pharmacology
  • Kinetics
  • Lipoxygenase / metabolism*
  • Male
  • Neutrophils / drug effects
  • Neutrophils / enzymology*
  • Prostaglandin-Endoperoxide Synthases / metabolism*
  • Rats
  • Structure-Activity Relationship

Substances

  • Anti-Inflammatory Agents
  • Arachidonic Acids
  • Lipoxygenase
  • Prostaglandin-Endoperoxide Synthases
  • Aspirin
  • Indomethacin