Abstract
Guinea pigs were sensitized to polygodial 1, a natural sesquiterpene dialdehyde, using intradermal injections in Freund's complete adjuvant. Cross-reactions with a (+/-)-mixture of warburganal and (-)-warburganal 2 (a natural hydroxylated derivative of polygodial) showed a high specificity of the allergic response since the (-)-pseudoenantiomer (having the same configuration as the primary sensitizer) gave a stronger skin reaction than the racemic mixture.
MeSH terms
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Allergens / toxicity*
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Animals
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Chemical Phenomena
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Chemistry
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Cross Reactions
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Dermatitis, Atopic / chemically induced*
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Dermatitis, Atopic / immunology
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Dermatitis, Contact / immunology*
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Drug Hypersensitivity / diagnosis*
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Female
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Guinea Pigs
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Hypersensitivity, Delayed / chemically induced
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Hypersensitivity, Delayed / diagnosis
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Intradermal Tests
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Plant Extracts / toxicity*
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Plants, Medicinal*
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Sesquiterpenes / toxicity*
Substances
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Allergens
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Plant Extracts
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Sesquiterpenes
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warburganal
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polygodial