Abstract
Three synthetic peptides, urotensin I, sauvagine and ovine CRF, have less than 50% sequence homology. In the dog, all three produce selective mesenteric dilation, which appears to be solely responsible for a decrease in peripheral resistance and systemic arterial blood pressure. Urotensin I and sauvagine were found to be 5-10 times more potent than CRF.
MeSH terms
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Amphibian Proteins
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Animals
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Blood Pressure / drug effects
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Corticotropin-Releasing Hormone / pharmacology*
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Dogs
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Hemodynamics / drug effects
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Peptide Hormones
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Peptides / pharmacology*
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Sheep
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Splanchnic Circulation / drug effects*
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Urotensins / pharmacology*
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Vascular Resistance / drug effects
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Vasodilator Agents*
Substances
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Amphibian Proteins
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Peptide Hormones
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Peptides
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Urotensins
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Vasodilator Agents
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sauvagine
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Corticotropin-Releasing Hormone
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urotensin I