Metabolism of (5E)-6a-carbaprostaglandin I2 by rhesus monkey lung 15-OH prostaglandin dehydrogenase

Prostaglandins. 1981 Apr;21(4):609-14. doi: 10.1016/0090-6980(81)90009-5.

Abstract

(5E)-6a-Carbaprostaglandin I2 (carbacyclin) was oxidized to (5E)-15-dehydro-6a-carbaprostaglandin I2 (15-dehydrocarbacyclin) by partially purified rhesus monkey lung prostaglandin dehydrogenase (PGDH). The (5E-15-dehydro-6a-carbaprostaglandin I2 was isolated by preparative thin-layer chromatography and identified by gas chromatography-mass spectrometry. A Lineweaver-Burke plot gave an apparent Km value of 2.9 microM and a Vmax of 35.7 nmoles carbacyclin oxidized/mg protein/min. These values are similar to previously reported Km and Vmax values for PGI2 and PGE1.

MeSH terms

  • Animals
  • Epoprostenol / metabolism*
  • Hydroxyprostaglandin Dehydrogenases / metabolism*
  • Kinetics
  • Lung / enzymology*
  • Macaca mulatta
  • Prostaglandins / metabolism*
  • Prostaglandins, Synthetic / metabolism

Substances

  • Prostaglandins
  • Prostaglandins, Synthetic
  • Epoprostenol
  • Hydroxyprostaglandin Dehydrogenases