Abstract
In the usual course of events, the liver detoxifies hepatocytotoxic intermediates of drug metabolism. But when protective systems are overloaded by normally harmless drugs, the intermediates can cause massive, even fatal, hepatic necrosis.
MeSH terms
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Acetaminophen / adverse effects
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Acetaminophen / metabolism
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Acetaminophen / toxicity
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Animals
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Chemical and Drug Induced Liver Injury / etiology*
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Chemical and Drug Induced Liver Injury / pathology
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Drug Hypersensitivity / etiology
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Drug-Related Side Effects and Adverse Reactions*
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Halothane / adverse effects
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Humans
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Isoniazid / adverse effects
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Liver / drug effects*
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Liver / metabolism
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Liver / pathology
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Methyldopa / adverse effects
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Mice
Substances
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Acetaminophen
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Methyldopa
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Halothane
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Isoniazid