Fifty-nine patients were studied who had severe tricuspid regurgitation which was confirmed by right ventriculography and during surgery in order to determine the incidence of clinical, radiologic, and hemodynamic clues of severe tricuspid regurgitation. Eighty-eight percent of patients had Carvallo sign alone or in combination with pulsatile liver or prominent jugular venous V waves, and the classic triad was present in 42 percent. Most patients had enlargement of the right atrium on chest x-ray film. The classical "ventricularization" pattern of right atrial pressure was seen in 30 percent, prominent V waves with rapid Y descents were present in 37 percent, and normal contour of right atrial waves with normal mean pressure was seen in 33 percent. The inspiratory maneuver was helpful to induce the ventricularization pattern or prominent V waves with rapid Y descents especially in patients with normal right atrial pressure waves. In conclusion, right ventriculography is a sensitive and accurate method for detecting and quantitating tricuspid regurgitation in the absence of the diagnostic physical findings.