Abstract
The stimulating effect on mitogen-induced lymphocyte response by polycationic compounds such as polylysine, DEAE dextran protamine and methylated albumin, is studied at different serum-protein concentrations and mitogen concentrations. It is suggested that the polar interaction between polycationic compounds and glycoproteins are of major importance for reactivity of lymphocytes to mitogens.
MeSH terms
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Anions / pharmacology*
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Cations / pharmacology*
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Cells, Cultured
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Ceruloplasmin / pharmacology
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Chondroitin Sulfates / pharmacology
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Dextrans / pharmacology
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Dose-Response Relationship, Drug
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Humans
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Lectins / pharmacology
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Lymphocyte Activation / drug effects*
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Polylysine / pharmacology
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Protamines / pharmacology
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Structure-Activity Relationship
Substances
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Anions
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Cations
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Dextrans
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Lectins
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Protamines
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Polylysine
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Chondroitin Sulfates
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Ceruloplasmin