Abstract
Antibody to the major purified cytochrome P-450 induced by 3-methylcholanthrene in rat liver strongly inhibits aryl hydrocarbon hydroxylase activity of uninduced and benz[a]anthracene-induced human monocytes and lymphocytes. Antibody to the cytochrome P-450 induced by phenobarbital has relatively little or no effect on the aryl hydrocarbon hydroxylase activity of the same human cells.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Antigen-Antibody Reactions
-
Aryl Hydrocarbon Hydroxylases / antagonists & inhibitors*
-
Aryl Hydrocarbon Hydroxylases / immunology
-
Benz(a)Anthracenes / pharmacology
-
Cytochrome P-450 Enzyme System / immunology*
-
Enzyme Induction / drug effects
-
Humans
-
Lymphocytes / enzymology*
-
Methylcholanthrene / pharmacology
-
Monocytes / enzymology*
-
Pentobarbital / pharmacology
-
Rats
Substances
-
Benz(a)Anthracenes
-
Methylcholanthrene
-
Cytochrome P-450 Enzyme System
-
Aryl Hydrocarbon Hydroxylases
-
Pentobarbital