Aryl hydrocarbon hydroxylase is inhibited by antibody to rat liver cytochrome P-450

Science. 1980 May 30;208(4447):1031-3. doi: 10.1126/science.7375915.

Abstract

Antibody to the major purified cytochrome P-450 induced by 3-methylcholanthrene in rat liver strongly inhibits aryl hydrocarbon hydroxylase activity of uninduced and benz[a]anthracene-induced human monocytes and lymphocytes. Antibody to the cytochrome P-450 induced by phenobarbital has relatively little or no effect on the aryl hydrocarbon hydroxylase activity of the same human cells.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antigen-Antibody Reactions
  • Aryl Hydrocarbon Hydroxylases / antagonists & inhibitors*
  • Aryl Hydrocarbon Hydroxylases / immunology
  • Benz(a)Anthracenes / pharmacology
  • Cytochrome P-450 Enzyme System / immunology*
  • Enzyme Induction / drug effects
  • Humans
  • Lymphocytes / enzymology*
  • Methylcholanthrene / pharmacology
  • Monocytes / enzymology*
  • Pentobarbital / pharmacology
  • Rats

Substances

  • Benz(a)Anthracenes
  • Methylcholanthrene
  • Cytochrome P-450 Enzyme System
  • Aryl Hydrocarbon Hydroxylases
  • Pentobarbital