Preoperative concomitant radiochemotherapy and IORT in locally advanced rectal cancer
Rays. 1995 Apr-Jun;20(2):197-207.
[Article in
English,
Italian]
Authors
F Crucitti
1
, L Sofo, C Ratto, G Battista Doglietto, R Bellantone, P Nucera, M Bossola, R Ranieri, W Perilli, L Azario, et al.
Affiliation
- 1 Istituto di Clinica Chirurgica Generale, Università Cattolica del S. Cuore, Policlinico A. Gemelli, Roma, Italy.
Abstract
34 patients with locally advanced (T4) or recurrent rectal cancer have been treated with: 1. external beam radiotherapy (45-48 Gy) + 5FU(1000 mg/m2/daily iv continuous infusion day 1-4) + MMC (10 mg/m2/daily iv, day 1); 2. surgical resection (if feasible) + IORT (10-15 Gy); 3. adjuvant chemotherapy (5FU+leucovorin, 6-8 cycles). Grade 3 acute hematological toxicity was observed in 1 case only. 23 of 34 patients underwent radical surgery. Perioperative mortality and morbidity was 0% and 17% respectively. In the 23 operated patients with a mean follow-up of 18.6 months there were 2 local recurrences, 5 blood metastases, (1 death of disease). 16 patients were shown to be NED (3-36 months).
MeSH terms
-
Antibiotics, Antineoplastic / administration & dosage
-
Antidotes / administration & dosage
-
Antimetabolites, Antineoplastic / administration & dosage
-
Chemotherapy, Adjuvant
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Combined Modality Therapy
-
Fluorouracil / administration & dosage
-
Follow-Up Studies
-
Humans
-
Leucovorin / administration & dosage
-
Lymph Node Excision
-
Mitomycin / administration & dosage
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Neoplasm Recurrence, Local
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Postoperative Care
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Preoperative Care
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Radiotherapy Dosage
-
Rectal Neoplasms / radiotherapy
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Rectal Neoplasms / surgery
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Rectal Neoplasms / therapy*
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Time Factors
Substances
-
Antibiotics, Antineoplastic
-
Antidotes
-
Antimetabolites, Antineoplastic
-
Mitomycin
-
Leucovorin
-
Fluorouracil