Abstract
Three metabolites were isolated from the culture broth of an actinomycete strain identified as Streptomyces platensis SANK 60191, that induce the production of colony-stimulating factors (CSFs) by stromal cell line KM-102 at ED50 concentrations from 40 to 200 ng/ml. The compounds induced quantities of granulocyte CSF (G-CSF) and granulocyte-macrophage CSF (GM-CSF) comparable to those induced by interleukin-1, a strong CSF inducer. These metabolites were called leustroducsins (A, B and C) and were later found to be structurally related to phoslactomycins. This is the first report of CSF inducing activity by members of the phoslactomycin class.
MeSH terms
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Antifungal Agents / pharmacology
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Bone Marrow / drug effects*
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Bone Marrow / metabolism
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Cell Line
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Fatty Acids, Unsaturated / chemistry
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Fatty Acids, Unsaturated / isolation & purification*
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Fatty Acids, Unsaturated / pharmacology
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Fermentation
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Granulocyte Colony-Stimulating Factor / biosynthesis*
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Granulocyte-Macrophage Colony-Stimulating Factor / biosynthesis*
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Humans
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Lactones / chemistry
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Lactones / isolation & purification
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Lactones / pharmacology
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Organophosphorus Compounds / chemistry
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Organophosphorus Compounds / isolation & purification
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Organophosphorus Compounds / pharmacology
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Pyrones
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Streptomyces / chemistry*
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Structure-Activity Relationship
Substances
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Antifungal Agents
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Fatty Acids, Unsaturated
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Lactones
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Organophosphorus Compounds
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Pyrones
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Granulocyte Colony-Stimulating Factor
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leustroducsin A
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leustroducsin B
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leustroducsin C
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Granulocyte-Macrophage Colony-Stimulating Factor
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leptomycin A