Abstract
Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells. Various cells express Fas, whereas FasL is expressed predominantly in activated T cells. In the immune system, Fas and FasL are involved in down-regulation of immune reactions as well as in T cell-mediated cytotoxicity. Malfunction of the Fas system causes lymphoproliferative disorders and accelerates autoimmune diseases, whereas its exacerbation may cause tissue destruction.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Antigens, Surface / chemistry
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Antigens, Surface / genetics
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Antigens, Surface / physiology*
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Apoptosis*
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Autoimmune Diseases / genetics
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Autoimmune Diseases / immunology
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Base Sequence
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Cytotoxicity, Immunologic
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Down-Regulation
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Fas Ligand Protein
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Humans
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Lymphocyte Activation
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Lymphocytes / cytology
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Lymphocytes / immunology*
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Lymphoproliferative Disorders / genetics
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Lymphoproliferative Disorders / immunology
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Membrane Glycoproteins / chemistry
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / physiology*
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Molecular Sequence Data
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T-Lymphocytes, Cytotoxic / immunology
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fas Receptor
Substances
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Antigens, Surface
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FASLG protein, human
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Fas Ligand Protein
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Membrane Glycoproteins
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fas Receptor