Ionophoretically applied substance P activates hamster suprachiasmatic nucleus neurons

Brain Res Bull. 1995;37(5):475-9. doi: 10.1016/0361-9230(95)00027-c.

Abstract

ionophoretic ejection of substance P (SP) activated 31% and suppressed 9% of hamster suprachiasmatic nucleus (SCN) cells in vitro. Hamster SCN cells did not demonstrate variation in sensitivity to SP across the circadian phases tested. SP modulated the response of 47% of hamster SCN cells to the excitatory amino acid (EAA) agonists glutamate and N-methyl-D-aspartate (NMDA). The results indicate that SP can alter both the spontaneous and EAA-evoked firing rate characteristics of hamster SCN neurons.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Action Potentials / drug effects
  • Animals
  • Circadian Rhythm / physiology
  • Cricetinae
  • In Vitro Techniques
  • Iontophoresis
  • Male
  • Mesocricetus
  • Microelectrodes
  • Neurons / drug effects*
  • Substance P / administration & dosage
  • Substance P / pharmacology*
  • Suprachiasmatic Nucleus / cytology
  • Suprachiasmatic Nucleus / drug effects
  • Suprachiasmatic Nucleus / physiology*

Substances

  • Substance P