Abstract
In the Drosophila embryo, activation of wingless and engrailed in the parasegment requires paired, a member of the Pax family of transcription factors. We have explored the possible conservation of this regulatory hierarchy in the developing mouse brain. We find that Pax-2 is expressed prior to somite formation in the presumptive mid/hindbrain region. Shortly thereafter, Wnt-1 (the wingless orthologue) and Engrailed-1 are expressed in overlapping regions within the Pax-2 domain. Pax-5 expression commences later, at the 3-somite stage. Thus, the spatial and temporal expression of Pax-2 is consistent with a possible regulatory role in the activation of Wnt-1 and En-1.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain / embryology*
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Brain / metabolism
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DNA-Binding Proteins / biosynthesis*
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DNA-Binding Proteins / genetics
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Embryonic and Fetal Development
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Female
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Gene Expression Regulation, Developmental
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Homeodomain Proteins / biosynthesis*
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Homeodomain Proteins / genetics
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Mice
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PAX2 Transcription Factor
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Pregnancy
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Proto-Oncogene Proteins / biosynthesis*
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Proto-Oncogene Proteins / genetics
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Transcription Factors / biosynthesis*
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Transcription Factors / genetics
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Wnt Proteins
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Wnt1 Protein
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Zebrafish Proteins*
Substances
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DNA-Binding Proteins
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En1 protein, mouse
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Homeodomain Proteins
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PAX2 Transcription Factor
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Pax2 protein, mouse
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Proto-Oncogene Proteins
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Transcription Factors
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Wnt Proteins
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Wnt1 Protein
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Wnt1 protein, mouse
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Zebrafish Proteins