Enhancement of phorbol ester-induced production of tumor necrosis factor-alpha by 2,6-dimethylphenylphthalimide

Biol Pharm Bull. 1994 Nov;17(11):1532-4. doi: 10.1248/bpb.17.1532.

Abstract

The effect of phenyl- and benzylphthalimide analogs on tumor necrosis factor (TNF)-alpha production by a human leukemia cell line, HL-60, stimulated with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was investigated. Though non-substituted phenyl- and benzyl-phthalimide had no effect on TNF-alpha production after TPA-induction, introduction of methyl group(s) onto the phenyl group resulted in the appearance of potent enhancing activity on TNF-alpha production.

MeSH terms

  • Cell Division / drug effects
  • Humans
  • Leukemia / metabolism
  • Phthalimides / chemistry
  • Phthalimides / pharmacology*
  • Structure-Activity Relationship
  • Tetradecanoylphorbol Acetate / pharmacology*
  • Tumor Cells, Cultured
  • Tumor Necrosis Factor-alpha / biosynthesis*
  • Xylenes / pharmacology*

Substances

  • Phthalimides
  • Tumor Necrosis Factor-alpha
  • Xylenes
  • 2,6-dimethylphenylphthalimide
  • Tetradecanoylphorbol Acetate