Characterization of cyclic AMP phosphodiesterase isozymes in rat parotid gland

Arch Oral Biol. 1995 Feb;40(2):165-8. doi: 10.1016/0003-9969(94)00139-3.

Abstract

Cyclic AMP phosphodiesterase (PDE) isozymes were isolated and characterized from the soluble fraction of rat parotid gland. Four main peaks containing PDE activity were obtained by Q-Sepharose Fast Flow column chromatography. The four peaks were identified as PDEs I-IV by kinetic properties, molecular-weight analysis and their responses to effectors and inhibitors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors
  • 3',5'-Cyclic-AMP Phosphodiesterases / chemistry
  • 3',5'-Cyclic-AMP Phosphodiesterases / isolation & purification*
  • 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone / pharmacology
  • Animals
  • Calcium / pharmacology
  • Calmodulin / pharmacology
  • Chromatography, Agarose
  • Cyclic GMP / pharmacology
  • Enzyme Activation
  • Isoenzymes / antagonists & inhibitors
  • Isoenzymes / chemistry
  • Isoenzymes / isolation & purification*
  • Kinetics
  • Male
  • Milrinone
  • Molecular Weight
  • Parotid Gland / enzymology*
  • Phosphodiesterase Inhibitors / pharmacology
  • Pyridones / pharmacology
  • Pyrrolidinones / pharmacology
  • Quinolones / pharmacology
  • Rats
  • Rats, Wistar
  • Rolipram

Substances

  • Calmodulin
  • Isoenzymes
  • Phosphodiesterase Inhibitors
  • Pyridones
  • Pyrrolidinones
  • Quinolones
  • 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
  • cilostamide
  • 3',5'-Cyclic-AMP Phosphodiesterases
  • Cyclic GMP
  • Milrinone
  • Rolipram
  • Calcium