Abstract
Cyclic AMP phosphodiesterase (PDE) isozymes were isolated and characterized from the soluble fraction of rat parotid gland. Four main peaks containing PDE activity were obtained by Q-Sepharose Fast Flow column chromatography. The four peaks were identified as PDEs I-IV by kinetic properties, molecular-weight analysis and their responses to effectors and inhibitors.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors
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3',5'-Cyclic-AMP Phosphodiesterases / chemistry
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3',5'-Cyclic-AMP Phosphodiesterases / isolation & purification*
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4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone / pharmacology
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Animals
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Calcium / pharmacology
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Calmodulin / pharmacology
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Chromatography, Agarose
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Cyclic GMP / pharmacology
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Enzyme Activation
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Isoenzymes / antagonists & inhibitors
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Isoenzymes / chemistry
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Isoenzymes / isolation & purification*
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Kinetics
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Male
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Milrinone
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Molecular Weight
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Parotid Gland / enzymology*
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Phosphodiesterase Inhibitors / pharmacology
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Pyridones / pharmacology
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Pyrrolidinones / pharmacology
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Quinolones / pharmacology
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Rats
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Rats, Wistar
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Rolipram
Substances
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Calmodulin
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Isoenzymes
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Phosphodiesterase Inhibitors
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Pyridones
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Pyrrolidinones
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Quinolones
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4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
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cilostamide
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3',5'-Cyclic-AMP Phosphodiesterases
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Cyclic GMP
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Milrinone
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Rolipram
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Calcium