Trachyspic acid, a new metabolite produced by Talaromyces trachyspermus, that inhibits tumor cell heparanase: taxonomy of the producing strain, fermentation, isolation, structural elucidation, and biological activity

J Antibiot (Tokyo). 1995 May;48(5):357-62. doi: 10.7164/antibiotics.48.357.

Abstract

Trachyspic acid, a new metabolite that inhibited heparanase, was isolated from the culture broth of Talaromyces trachyspermus SANK 12191. Its structure was deduced from NMR spectral analyses and chemical reactions as a tricarboxylic acid derivative containing a spiroketal. The IC50 value of trachyspic acid against heparanase was 36 microM.

MeSH terms

  • Ascomycota / metabolism
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification*
  • Enzyme Inhibitors / pharmacology
  • Fermentation
  • Glucuronidase*
  • Glycoside Hydrolases / antagonists & inhibitors*
  • Magnetic Resonance Spectroscopy
  • Melanoma, Experimental / enzymology
  • Spiro Compounds / chemistry
  • Spiro Compounds / isolation & purification*
  • Spiro Compounds / pharmacology
  • Structure-Activity Relationship

Substances

  • Enzyme Inhibitors
  • Spiro Compounds
  • trachyspic acid
  • Glycoside Hydrolases
  • heparanase
  • Glucuronidase