Abstract
Trachyspic acid, a new metabolite that inhibited heparanase, was isolated from the culture broth of Talaromyces trachyspermus SANK 12191. Its structure was deduced from NMR spectral analyses and chemical reactions as a tricarboxylic acid derivative containing a spiroketal. The IC50 value of trachyspic acid against heparanase was 36 microM.
MeSH terms
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Ascomycota / metabolism
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification*
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Enzyme Inhibitors / pharmacology
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Fermentation
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Glucuronidase*
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Glycoside Hydrolases / antagonists & inhibitors*
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Magnetic Resonance Spectroscopy
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Melanoma, Experimental / enzymology
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Spiro Compounds / chemistry
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Spiro Compounds / isolation & purification*
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Spiro Compounds / pharmacology
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Structure-Activity Relationship
Substances
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Enzyme Inhibitors
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Spiro Compounds
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trachyspic acid
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Glycoside Hydrolases
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heparanase
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Glucuronidase