Human cortical neuronal (HCN) cell lines: a model for amyloid beta neurotoxicity

Z Zhang; G J Drzewiecki; J T Hom; P C May; P A Hyslop

doi:10.1016/0304-3940(94)90892-3

Human cortical neuronal (HCN) cell lines: a model for amyloid beta neurotoxicity

Neurosci Lett. 1994 Aug 15;177(1-2):162-4. doi: 10.1016/0304-3940(94)90892-3.

Authors

Z Zhang¹, G J Drzewiecki, J T Hom, P C May, P A Hyslop

Affiliation

¹ Department of Central Nervous System Research, Lilly Research Laboratory, Lilly Corporate Center, Indianapolis, IN 46285.

PMID: 7824173
DOI: 10.1016/0304-3940(94)90892-3

Abstract

Human cortical neuronal cell lines HCN-1A and HCN-2 are killed for following exposure of the differentiated cells to amyloid beta-peptide(1-40), a component of senile plaques and other amyloid deposits in brains from Alzheimer's patients. We present a model of A beta toxicity uncomplicated by the presence of other cell types that can be used to address the mechanism of A beta neurotoxicity. This model will be useful in the evaluation of neuroprotective compounds which may attenuate cortical neuronal loss in Alzheimer's disease.

Publication types

Comparative Study

MeSH terms

Amyloid beta-Peptides / toxicity*
Biomarkers
Cell Death
Cell Line
Child
Child, Preschool
Female
Humans
Infant
Neurons / drug effects*
Peptide Fragments / toxicity*

Substances

Amyloid beta-Peptides
Biomarkers
Peptide Fragments
amyloid beta-protein (1-40)