Enhancement of 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor alpha production by phenethylphthalimide analogs

K Sasaki; Y Shibata; K Nishimura; Y Hashimoto; S Iwasaki

doi:10.1248/bpb.17.1313

Enhancement of 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor alpha production by phenethylphthalimide analogs

Biol Pharm Bull. 1994 Sep;17(9):1313-5. doi: 10.1248/bpb.17.1313.

Authors

K Sasaki¹, Y Shibata, K Nishimura, Y Hashimoto, S Iwasaki

Affiliation

¹ Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.

PMID: 7841962
DOI: 10.1248/bpb.17.1313

Abstract

Effects of phenyl-, benzyl-, phenethyl-, and phenylpropylphthalimides on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumor necrosis factor (TNF)-alpha production by human leukemia cell line HL-60 were examined. Among the four phthalimide derivatives, only phenethylphthalimide showed potent enhancing effect on TNF-alpha production.

MeSH terms

Humans
Leukemia, Experimental / metabolism
Phthalimides / chemical synthesis
Phthalimides / pharmacology*
Structure-Activity Relationship
Tetradecanoylphorbol Acetate / pharmacology*
Tumor Cells, Cultured
Tumor Necrosis Factor-alpha / biosynthesis*

Substances

Phthalimides
Tumor Necrosis Factor-alpha
Tetradecanoylphorbol Acetate