GABAA receptor beta 1-3 subunit gene expression in the hippocampus of kindled rats

Neurosci Lett. 1994 Jun 6;174(1):5-8. doi: 10.1016/0304-3940(94)90105-8.

Abstract

The effect of Schaffer collateral/commissural fiber kindling on the expression levels of GABAA receptor beta 1, beta 2 and beta 3 subunit mRNA in the pyramidal and granular neurons of the rat dorsal hippocampus was studied, using semi-quantitative in situ hybridization. In pyramidal neurons of CA1 and CA3, only small changes (10-15%) were found. In dentate granule neurons, the expression level of GABAA R-beta 3 mRNA was significantly, enhanced, bilaterally, in animals that were partial or fully kindled. At long-term, 4 weeks after the last convulsion no significant changes were found in pyramidal or granular neurons.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Gene Expression / physiology*
  • Hippocampus / cytology
  • Hippocampus / metabolism*
  • In Situ Hybridization
  • In Vitro Techniques
  • Kindling, Neurologic / physiology*
  • Male
  • Pyramidal Cells / metabolism
  • RNA, Messenger / biosynthesis
  • Rats
  • Rats, Wistar
  • Receptors, GABA-A / biosynthesis*
  • Receptors, GABA-A / genetics

Substances

  • RNA, Messenger
  • Receptors, GABA-A