Abstract
We have cloned a human cDNA fragment for a gene that is expressed primarily in the heart. To explore its biological function, we have isolated full-length cDNA clones of the gene. DNA sequencing of the 2.7-kb cDNA revealed a 2274-bp ORF. Close to the N terminus of the deduced amino acid sequence is a possible ATP-binding domain that has been assembled by a fusion of B- and A-type adenine nucleotide-binding motifs. In the middle of the sequence is a long stretch of alpha-helical residues that could form a coiled-coil. These features imply that this is a sequence encoding a new human motor protein.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine Triphosphate / metabolism
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Amino Acid Sequence
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Animals
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Base Sequence
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Cell Line
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DNA, Complementary
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Humans
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Mitochondrial Proteins
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Molecular Sequence Data
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Muscle Proteins / genetics*
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Muscle Proteins / metabolism
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Myocardium / metabolism*
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Protein Structure, Secondary
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Rats
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Sequence Analysis, DNA
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Sequence Homology, Amino Acid
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Transcription, Genetic*
Substances
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DNA, Complementary
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IMMT protein, human
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Mitochondrial Proteins
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Muscle Proteins
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Adenosine Triphosphate
Associated data
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GENBANK/D11750
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GENBANK/D21091
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GENBANK/D21092
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GENBANK/D21093
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GENBANK/D21094
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GENBANK/M85372
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GENBANK/M85406
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GENBANK/Z19322