Abstract
The temperature sensitivity of human papillomavirus type 11 was evaluated by using a human xenograft severe combined immunodeficiency mouse model. Incubation of the virus for 1 h at a temperature higher than 56 degrees C but lower than 72 degrees C was sufficient to inhibit the virally induced growth of infected human tissue. However, 100 degrees C was necessary to completely inactivate HPV type 11 genome expression.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Base Sequence
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Condylomata Acuminata / virology*
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DNA Probes, HPV
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Humans
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Male
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Mice
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Mice, SCID*
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Molecular Sequence Data
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Papillomaviridae / classification
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Papillomaviridae / physiology*
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Penile Neoplasms / virology*
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Severe Combined Immunodeficiency / virology
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Skin / virology
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Skin Transplantation
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Subrenal Capsule Assay
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Temperature*
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Transplantation, Heterologous