Evaluation of temperature sensitivity of human papillomavirus type 11 by using the human xenograft severe combined immunodeficiency mouse model

J Clin Microbiol. 1994 Jun;32(6):1575-7. doi: 10.1128/jcm.32.6.1575-1577.1994.

Abstract

The temperature sensitivity of human papillomavirus type 11 was evaluated by using a human xenograft severe combined immunodeficiency mouse model. Incubation of the virus for 1 h at a temperature higher than 56 degrees C but lower than 72 degrees C was sufficient to inhibit the virally induced growth of infected human tissue. However, 100 degrees C was necessary to completely inactivate HPV type 11 genome expression.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Condylomata Acuminata / virology*
  • DNA Probes, HPV
  • Humans
  • Male
  • Mice
  • Mice, SCID*
  • Molecular Sequence Data
  • Papillomaviridae / classification
  • Papillomaviridae / physiology*
  • Penile Neoplasms / virology*
  • Severe Combined Immunodeficiency / virology
  • Skin / virology
  • Skin Transplantation
  • Subrenal Capsule Assay
  • Temperature*
  • Transplantation, Heterologous

Substances

  • DNA Probes, HPV