Abstract
Dynorphin A derivatives containing S-(3-nitro-2-pyridinesulfenyl)-cysteine(Cys(Npys)) were designed and synthesized for affinity labeling of kappa opioid receptors. Derivatives with Cys(Npys) residue at the 8 position were highly potent and specific to kappa receptors and bound to receptors through disulfide bond formation.
MeSH terms
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Affinity Labels / chemical synthesis*
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Amino Acid Sequence
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Animals
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Drug Design
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Dynorphins / analogs & derivatives*
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Dynorphins / chemical synthesis*
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Guinea Pigs
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In Vitro Techniques
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Molecular Sequence Data
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Rabbits
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Receptors, Opioid, kappa / drug effects*
Substances
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Affinity Labels
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Receptors, Opioid, kappa
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Dynorphins