Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes

Science. 1994 Mar 11;263(5152):1453-4. doi: 10.1126/science.8128231.

Abstract

The gamma chain of the interleukin-2 (IL-2) receptor is shared with the functional IL-4 receptor and is causatively related to X-linked severe combined immunodeficiency (XSCID), which is ascribed to a profound T cell defect. Studies with monoclonal antibodies specific for the IL-2 receptor gamma chain showed that the gamma chain participates in the functional high-affinity receptor complexes for IL-7 that are involved in the differentiation of T and B cells. Participation of the gamma subunit in more than one receptor may enable the elucidation of the mechanisms of XSCID development and lymphocyte differentiation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal
  • B-Lymphocytes / immunology*
  • Cell Line
  • Cells, Cultured
  • Female
  • Genetic Linkage
  • Interleukin-7 / metabolism*
  • Interleukin-7 / pharmacology
  • Mice
  • Mice, Inbred C57BL
  • Receptors, Interleukin / metabolism*
  • Receptors, Interleukin-2 / genetics
  • Receptors, Interleukin-2 / immunology
  • Receptors, Interleukin-2 / metabolism*
  • Receptors, Interleukin-7
  • Severe Combined Immunodeficiency / genetics
  • Severe Combined Immunodeficiency / immunology
  • T-Lymphocytes / immunology*
  • X Chromosome

Substances

  • Antibodies, Monoclonal
  • Interleukin-7
  • Receptors, Interleukin
  • Receptors, Interleukin-2
  • Receptors, Interleukin-7