We report five cases of cat-scratch disease encephalopathy (CSDE), with a brief review of the literature in English, in which only 96 patients of CSDE have been described up to the present. The Gram-negative bacilli demonstrated by Warthin-Starry or Dieterle silver stains are regarded as the causative agent of CSDE. Administration of antibiotics is recommended. The onset of CSDE is usually acute and the prognosis favorable.