Abstract
Streptomyces hygroscopicus subsp. aureolacrimosus SANK 60286 produces a new family of milbemycins, named milbemycins alpha 11, alpha 12 [corrected], alpha 13, alpha 14 and alpha 15, together with other milbemycins. Their structures are 3-methyl-2-butenoyloxy and 3-methylbutyroyloxy derivatives at C-4a of milbemycins A3 and A4, or 3-methyl-2-pentenoyloxy derivative at C-4a of milbemycin A3, respectively. Milbemycin alpha 14, 3-methyl-2-butenoyloxy derivative, especially possesses a potent acaricidal activity.
MeSH terms
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Animals
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Anthelmintics / chemistry
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Anthelmintics / isolation & purification*
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Anthelmintics / pharmacology
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Caenorhabditis elegans / drug effects
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Chromatography, High Pressure Liquid
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Fermentation
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Macrolides
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Magnetic Resonance Spectroscopy
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Microscopy, Electron, Scanning
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Mites / drug effects
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Molecular Structure
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Streptomyces / chemistry
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Streptomyces / classification
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Streptomyces / metabolism*
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Streptomyces / ultrastructure
Substances
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Anthelmintics
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Anti-Bacterial Agents
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Macrolides
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moxidectin