Adaptation of Escherichia coli to the uncoupler of oxidative phosphorylation 2,4-dinitrophenol

J Bacteriol. 1993 Nov;175(21):7105-8. doi: 10.1128/jb.175.21.7105-7108.1993.

Abstract

Escherichia coli was found to adapt to the uncoupler of oxidative phosphorylation 2,4-dinitrophenol. The rates of synthesis of 53 proteins were increased following exposure to 2,4-dinitrophenol. Adaptation was accelerated when the cofactor pyrroloquinoline quinone was provided in the growth medium.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 2,4-Dinitrophenol
  • Acclimatization
  • Bacterial Proteins / biosynthesis*
  • Bacterial Proteins / isolation & purification
  • Coenzymes / pharmacology
  • Dinitrophenols / toxicity*
  • Enzymes / biosynthesis
  • Escherichia coli / drug effects*
  • Escherichia coli / growth & development
  • Escherichia coli / metabolism
  • Genes, Bacterial
  • Kinetics
  • Methionine / metabolism
  • PQQ Cofactor
  • Quinolones / pharmacology*
  • Sulfur Radioisotopes
  • Uncoupling Agents / toxicity*

Substances

  • Bacterial Proteins
  • Coenzymes
  • Dinitrophenols
  • Enzymes
  • Quinolones
  • Sulfur Radioisotopes
  • Uncoupling Agents
  • PQQ Cofactor
  • Methionine
  • 2,4-Dinitrophenol