Low levels of specific T cell activation marker CD27 accompanied by elevated levels of markers for non-specific immune activation in the cerebrospinal fluid of patients with AIDS dementia complex

J Neuroimmunol. 1993 Nov-Dec;48(2):241-7. doi: 10.1016/0165-5728(93)90198-8.

Abstract

Concentrations of soluble receptors for tumor necrosis factor (sTNFR-p55 and sTNFR-p75) and soluble T cell antigens CD25 and CD27 (sCD25 and sCD27) were measured in paired serum/cerebrospinal fluid (CSF) samples of 15 patients with AIDS dementia complex (ADC) and 15 HIV-infected control subjects (11 with other central nervous system (CNS) infections and four without CNS infection). In this study levels of sTNFR-p55, sTNFR-p75 and sCD25 were elevated in the CSF of ADC patients and of the 11 patients with other CNS infections, whereas CSF-levels of the specific T cell marker sCD27 were lower in patients with ADC as compared to the control subjects with and without other CNS infections. This pattern suggests a relative failure of eliciting a T cell-mediated immune response intrathecally in patients with ADC.

MeSH terms

  • AIDS Dementia Complex / cerebrospinal fluid*
  • HIV Infections / cerebrospinal fluid
  • Humans
  • Receptors, Interleukin-2 / immunology
  • Receptors, Tumor Necrosis Factor / immunology
  • T-Lymphocyte Subsets
  • Tumor Necrosis Factor Receptor Superfamily, Member 7 / cerebrospinal fluid*

Substances

  • Receptors, Interleukin-2
  • Receptors, Tumor Necrosis Factor
  • Tumor Necrosis Factor Receptor Superfamily, Member 7