Abstract
In four patients, platelet aggregation with arachidonate was absent but was normal with "Labile Aggregation Stimulating Substance". ADP (10muM) aggregation was always reversible; collagen aggregation was absent and those induced by thrombin and ristocetin were normal. Collagen did not induce 14C-serotonin release but there was some release with thrombin. There was no thromboxan B2 synthesis in these platelets. Two patients showed hereditary hemostasis defect and the others acquired cyclo-oxygenase deficiency.
MeSH terms
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Adenosine Diphosphate / pharmacology
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Adult
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Arachidonic Acids / metabolism
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Blood Platelet Disorders / enzymology*
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Blood Platelets / enzymology
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Collagen / pharmacology
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Cytoplasmic Granules
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Female
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Humans
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Lipoxygenase / blood
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Lipoxygenase / deficiency*
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Microsomes / enzymology
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Peroxides / metabolism
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Platelet Aggregation*
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Prostaglandins / metabolism
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Ristocetin / pharmacology
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Thrombin / pharmacology
Substances
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Arachidonic Acids
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Peroxides
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Prostaglandins
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Ristocetin
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Adenosine Diphosphate
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Collagen
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Lipoxygenase
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Thrombin