Abstract
Thiomarinol, an antimicrobial antibiotic, was isolated from the culture broth of a marine bacterium, Alteromonas rava sp. nov. SANK 73390. Its structure was deduced as a hybrid composed of a pseudomonic acid analogue and holothin by NMR spectral analysis and chemical degradation. Antimicrobial activity against Gram-positive and Gram-negative bacteria of thiomarinol was stronger than both of pseudomonic acids and pyrrothine antibiotics.
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology*
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Chemical Phenomena
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Chemistry, Physical
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Fermentation
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Gram-Negative Aerobic Bacteria / chemistry*
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Gram-Negative Aerobic Bacteria / metabolism
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Lactams
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Mupirocin / analogs & derivatives*
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Mupirocin / chemistry
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Mupirocin / isolation & purification
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Mupirocin / pharmacology
Substances
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Anti-Bacterial Agents
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Lactams
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thiomarinol
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Mupirocin