On the potential role of proopiomelanocortin in skin physiology and pathology

Mol Cell Endocrinol. 1993 May;93(1):C1-6. doi: 10.1016/0303-7207(93)90131-3.

Abstract

Pro-opiomelanocortin (POMC) is the precursor of ACTH, alpha-MSH and beta-endorphin, neuropeptides with multiple regulatory functions. Both the pituitary gland and peripheral tissues such as mammalian skin are capable of generating POMC-derived neuropeptides. Mammalian skin is also a target for POMC products; their possible roles in skin physiology and pathology are discussed in this communication.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Consensus Sequence
  • Gene Expression Regulation
  • Humans
  • Mammals / physiology
  • Mice
  • Molecular Sequence Data
  • Neuroimmunomodulation / physiology
  • Neuropeptides / physiology
  • Pro-Opiomelanocortin / physiology*
  • Protein Processing, Post-Translational
  • Receptors, Cell Surface / physiology
  • Skin / pathology
  • Skin Neoplasms / physiopathology
  • Skin Physiological Phenomena*
  • Skin Pigmentation / physiology

Substances

  • Neuropeptides
  • Receptors, Cell Surface
  • Pro-Opiomelanocortin