Abstract
Pro-opiomelanocortin (POMC) is the precursor of ACTH, alpha-MSH and beta-endorphin, neuropeptides with multiple regulatory functions. Both the pituitary gland and peripheral tissues such as mammalian skin are capable of generating POMC-derived neuropeptides. Mammalian skin is also a target for POMC products; their possible roles in skin physiology and pathology are discussed in this communication.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Consensus Sequence
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Gene Expression Regulation
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Humans
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Mammals / physiology
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Mice
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Molecular Sequence Data
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Neuroimmunomodulation / physiology
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Neuropeptides / physiology
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Pro-Opiomelanocortin / physiology*
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Protein Processing, Post-Translational
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Receptors, Cell Surface / physiology
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Skin / pathology
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Skin Neoplasms / physiopathology
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Skin Physiological Phenomena*
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Skin Pigmentation / physiology
Substances
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Neuropeptides
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Receptors, Cell Surface
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Pro-Opiomelanocortin