Identification and differential expression of yeast SEC23-related gene (Msec23) in mouse tissues

FEBS Lett. 1993 Jan 4;315(2):193-6. doi: 10.1016/0014-5793(93)81161-r.

Abstract

We have isolated a yeast SEC23-related clone (Msec23) from mouse fibroblast cDNA library. It has an open reading frame of 1721 bp (64% homologous to SEC23-2.3 kb) which can potentially encode a 64.7 kDa protein (61% homologous to 85.4 kDa product of SEC23). The deduced Msec23 protein (Msec23p) sequence contains three successive Ig-like domains at the N-terminus followed by amphipathic alpha-helical regions, suggesting the potential of Msec23p to interact with other protein components. Further, Msec23 is differentially expressed in mouse tissues with its high level in brain and fibroblasts.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • COP-Coated Vesicles
  • Cloning, Molecular
  • DNA / genetics
  • Fungal Proteins / genetics
  • GTPase-Activating Proteins
  • Gene Expression
  • Mice
  • Molecular Sequence Data
  • Proteins / genetics*
  • Proteins / metabolism*
  • RNA, Messenger / genetics
  • Saccharomyces cerevisiae Proteins*
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Tissue Distribution
  • Vesicular Transport Proteins

Substances

  • Fungal Proteins
  • GTPase-Activating Proteins
  • Proteins
  • RNA, Messenger
  • SEC23 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Sec23a protein, mouse
  • Vesicular Transport Proteins
  • DNA

Associated data

  • GENBANK/D12713