Submandibular salivary gland hypertrophy induced by phenytoin

A H Brandenburg; M G Smits; B S Voorbrood; A M Hemmes; J J Ros

doi:10.1111/j.1528-1157.1993.tb02388.x

Submandibular salivary gland hypertrophy induced by phenytoin

Epilepsia. 1993 Jan-Feb;34(1):151-2. doi: 10.1111/j.1528-1157.1993.tb02388.x.

Authors

A H Brandenburg¹, M G Smits, B S Voorbrood, A M Hemmes, J J Ros

Affiliation

¹ Department of Pediatrics, Gelderse Vallei Hospital, Ede, The Netherlands.

PMID: 8422848
DOI: 10.1111/j.1528-1157.1993.tb02388.x

Abstract

A 16-year-old boy with epilepsy developed hypertrophy of the submandibular salivary glands, with high phenytoin (PHT) serum levels. The submandibular salivary glands became normal in 12 days after discontinuation of PHT. Other causes of salivary gland hypertrophy were excluded and we suggest that the hypertrophy was due to PHT.

Publication types

Case Reports

MeSH terms

Adolescent
Epilepsy, Complex Partial / drug therapy*
Humans
Hypertrophy / pathology
Male
Phenytoin / adverse effects*
Salivary Gland Diseases / chemically induced*
Submandibular Gland / pathology*

Substances

Phenytoin