Intestinal transplantation has become a viable treatment modality for the patient with short gut syndrome. The potential for the development of serious postoperative complications contributes to the complexity of caring for these patients. Through astute observation, thorough assessment, and intelligent intervention, the nurse can directly affect the ultimate success of intestinal transplantation. A dedicated team approach, along with a sincere patient/family commitment, will help to provide for optimal patient management and a successful outcome.