Abstract
Background:
Intensive antineoplastic regimens have enhanced long-term survival in pediatric patients with cancer, but can result in long-term complications. Esophageal stricture formation is one such complication.
Methods:
We reviewed the experience with benign esophageal stricture in pediatric patients with cancer over the past 15 years in a major cancer center. Clinical course, along with endoscopic, radiologic, and manometric esophageal studies, was reviewed.
Results:
Esophageal strictures formed in five pediatric patients who were treated with radiation and/or chemotherapy. Stricture formation was associated with abnormal esophageal motility in four out of the five patients. Repeated esophageal dilation was performed from 3-50 times and resulted in stricture resolution in only 2 of the 5 patients.
Conclusions:
Esophageal stricture formation in this population is rare, but is associated with long-term morbidity.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / adverse effects*
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Child
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Child, Preschool
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Combined Modality Therapy
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Esophageal Motility Disorders / chemically induced
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Esophageal Motility Disorders / diagnosis
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Esophageal Motility Disorders / etiology
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Esophageal Neoplasms / drug therapy
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Esophageal Neoplasms / radiotherapy
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Esophageal Stenosis / chemically induced*
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Esophageal Stenosis / diagnosis
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Esophageal Stenosis / etiology*
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Esophagitis / chemically induced
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Esophagitis / diagnosis
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Esophagitis / etiology
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Female
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Hodgkin Disease / drug therapy
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Hodgkin Disease / radiotherapy
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Humans
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Male
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Manometry
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Neoplasms / drug therapy*
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Neoplasms / radiotherapy*
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Oropharyngeal Neoplasms / drug therapy
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Oropharyngeal Neoplasms / radiotherapy
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Palatal Neoplasms / drug therapy
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Palatal Neoplasms / radiotherapy
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / radiotherapy
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Radiation Injuries / etiology*
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Rhabdomyosarcoma / drug therapy
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Rhabdomyosarcoma / radiotherapy
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Tracheal Neoplasms / drug therapy
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Tracheal Neoplasms / radiotherapy