Abstract
We cloned the human xeroderma pigmentosum group A gene (XPA) and characterized the XPA promoter (pXPA) by transient cat expression. The pXPA is extraordinarily weak in human fibroblasts (1% of RSV-LTR) and appears to function without any of the usual promoter elements. Regions containing positive and negative control elements were localized.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Base Sequence
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DNA-Binding Proteins / genetics*
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Gene Expression Regulation
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Molecular Sequence Data
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Promoter Regions, Genetic*
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RNA, Messenger / genetics
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Restriction Mapping
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Xeroderma Pigmentosum / genetics*
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Xeroderma Pigmentosum Group A Protein
Substances
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DNA-Binding Proteins
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RNA, Messenger
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Xeroderma Pigmentosum Group A Protein
Associated data
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GENBANK/U10343
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GENBANK/U10344
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GENBANK/U10345
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GENBANK/U10346
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GENBANK/U10347
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GENBANK/U16815